Abstract
The Impact of Parental Non-Alcoholic Fatty Liver Disease and Alcoholic Liver Disease on the risk of Fatty Liver Disease in their offspring: A Meta-Analysis
Ma. Regina Dimaculangan, MD; Nikko Theodore Raymundo, MD; Joseph Erwin Dumagpi, MD; Juliet Gopez-Cervantes, MD
St. Luke’s Medical Center – Global City
Significance: Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are major liver pathologies, both characterized by abnormal fat accumulation in the liver, which can progress to cirrhosis or hepatocellular carcinoma. Emerging evidence suggests that a parental history of liver disease may increase the risk of fatty liver disease in offspring, implicating both genetic and environmental factors. This meta-analysis aims to assess the impact of parental NAFLD and ALD on the risk of developing fatty liver disease in their children.
Methodology: A comprehensive search of literature was conducted through multiple electronic databases and grey literature sources until December 2023. Three cohort studies were included in the analysis, and RevMan 5.4 was used for statistical computation.
Results: The cohort studies by Long, Park, and Jepsen demonstrated that offspring of patients with NAFLD or ALD had nearly a two-fold increased risk of developing fatty liver disease. The I² value of 57% indicated moderate heterogeneity, prompting a subgroup analysis of the two studies on NAFLD alone, which yielded an I² of 0% (p=0.001). The pooled odds ratio was 2.25 (95% CI 1.63 to 3.10), which was statistically significant, indicating that a family history of NAFLD significantly increases the risk of fatty liver disease in offspring.
Conclusion: This study highlights a significant association between parental NAFLD (especially) and ALD with increased risk of fatty liver disease in offspring. These findings emphasize the need for early screening and preventive measures for families with a history of liver disease.
Important Dates to Remember
| JRRE Activities 2023-2024 |
Proposed Dates |
|---|---|
| Resumption of face-to-face Evidence-Based Medicine Workshop Venue to be announced once finalized. |
July 21, 2023 (Friday), 1-5pm |
| Monthly Critical Appraisal of Topics Conferences to be gaciliated by Research Coordinators per Institution | Monthly Critical Appraisal of Topics Conferences per Institution |
| CAT Plenary/Liver Con Dates: September 23, 2023 December 16, 2023 March 2024 (During the JAC) Resumption of face-to-face Quarterly Critical Appraisal of Topics facilitated by the JRRE |
2 Clinical scenarios and articles are to be sent to institutions each on August 2023, November 2023, and February 2024; |
| Hybrid Research Workshop 4 week asynchronous via Moodle, followed by a 1 day on-site Onsite Workshop Research Protocol Presentation for Level I GI Fellows-In-Training - Research Protocol Presentation: August 12, 2023 - Research Forums of the Tripartite Societies |
Week 1: July 15-21, 2023 Week 2: July 22-28, 2023 Week 3: July 29-August 4, 2023 Week 4: August 5-11, 2023 |
| Research Manuscript Workshop for level II GI Fellows-In-Training | January 6, 2024 |