Abstract
Factors Associated with Colorectal Adenoma in the Young: A Single-Center Case-Control Study
Ronell Lee, MD; Jose Tan, MD
Chinese General Hospital and Medical Center
Significance: The rising incidence of colorectal adenomas, precursors to colorectal cancer, in individuals under 45 years old necessitates targeted screening strategies. This study aimed to identify risk factors associated with colorectal adenomas in this age group to enhance early detection and intervention.
Methodology: A retrospective case-control study conducted at Chinese General Hospital from January 2019 to July 2024. Patients aged <45 years with complete medical records. Cases were patients with histopathologically confirmed adenomas, and controls were patients without adenomas matched 1:1.
Results: The study included 106 patients. Family history of colorectal cancer was significantly associated with colorectal adenomas (Adjusted OR: 3.14, 95% CI: 1.29–9.81, p = 0.014). Other factors, including BMI, smoking, alcohol intake, hypertension, and diabetes, showed no significant associations after adjustment. A trend of higher prevalence in overweight individuals was noted but was not statistically significant.
Conclusion: Family history of colorectal cancer is a critical risk factor for colorectal adenomas in individuals under 45 years. Screening programs should prioritize this population to improve early detection and reduce cancer progression. Future research should explore the role of genetic predisposition and other modifiable risk factors in younger populations.
Important Dates to Remember
| JRRE Activities 2023-2024 |
Proposed Dates |
|---|---|
| Resumption of face-to-face Evidence-Based Medicine Workshop Venue to be announced once finalized. |
July 21, 2023 (Friday), 1-5pm |
| Monthly Critical Appraisal of Topics Conferences to be gaciliated by Research Coordinators per Institution | Monthly Critical Appraisal of Topics Conferences per Institution |
| CAT Plenary/Liver Con Dates: September 23, 2023 December 16, 2023 March 2024 (During the JAC) Resumption of face-to-face Quarterly Critical Appraisal of Topics facilitated by the JRRE |
2 Clinical scenarios and articles are to be sent to institutions each on August 2023, November 2023, and February 2024; |
| Hybrid Research Workshop 4 week asynchronous via Moodle, followed by a 1 day on-site Onsite Workshop Research Protocol Presentation for Level I GI Fellows-In-Training - Research Protocol Presentation: August 12, 2023 - Research Forums of the Tripartite Societies |
Week 1: July 15-21, 2023 Week 2: July 22-28, 2023 Week 3: July 29-August 4, 2023 Week 4: August 5-11, 2023 |
| Research Manuscript Workshop for level II GI Fellows-In-Training | January 6, 2024 |