Abstract
Prognostic Relevance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Acute Pancreatitis
Dovenne Jade Cania, MD; Angela Lian Go, MD; Lawrence Chad Liu, MD
Cebu Doctors University Hospital
Significance: Acute Pancreatitis is a common inflammatory disease of the pancreas. Neutrophil-to-lymphocyte ratio (NLR) and Platelet-to-lymphocyte ratio (PLR) are emerging parameters of inflammatory reaction and has correlation with disease severity and mortality among diseases. This study aimed to determine the NLR and PLR of patients admitted in a tertiary hospital in Cebu for Acute Pancreatitis and its relation to the course, severity, and outcome of the disease.
Methodology: This was a retrospective, analytical, cohort study performed in Cebu Doctors’ University Hospital, a tertiary private hospital in Cebu City, Philippines. A chart review of patients admitted between January 2019 to December 2023 which included 188 patients. The NLR and the PLR were calculated as the ratio of neutrophil count to lymphocyte count and as the ratio of platelet count to lymphocyte count, respectively. Admitting laboratory results, demographics, etiology of pancreatitis, comorbidities, duration of hospital stay, and outcome measure (including development of shock, ICU admission, and all-cause mortality) were noted from chart review.
Results: Neither NLR nor PLR showed a statistically significant association with shock, ICU admission, or in-hospital mortality in patients with acute pancreatitis, as none of the p-values reached the significance threshold of 0.05. This suggests that while there are slight trends, neither NLR nor PLR is a reliable predictor for these severe outcomes in this sample.
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