Abstract
ASSOCIATION OF COLONIC DIVERTICULOSIS AND COLONIC ADENOMA: A CROSS-SECTIONAL STUDY IN PHILIPPINE GENERAL HOSPITAL
RA BARTOLOME, JJR TORRES, VP BANEZ
UNIVERSITY OF THE PHILIPPINES-PHILIPPINE GENERAL HOSPITAL
Significance: An association between colonic diverticulosis and colonic adenoma was demonstrated in many studies. However, findings in other studies yielded conflicting results. The study aims to to determine the association of diverticulosis and colonic adenoma.
Methodology: All patients who underwent colonoscopy in PGH between January 2017 and December 2017 were screened for eligibility. Patients with incomplete colonoscopy examination, inadequate bowel preparation, history of prior colonic resection, repeated colonoscopy within one year, colorectal malignancy, inflammatory bowel disease were excluded. The estimated sample size was 948. The crude OR was estimated at 95% confidence level to determine the association of diverticulosis and colonic adenoma. Likewise, adjusted OR was estimated at the same confidence level using logistic regression.
Results: A total of 990 patients were included in the study. The mean age is 53.5 years and 54% are males. A total of 128 patients (13%) have diverticulosis. A total of 167 (16.9%) were found to have adenoma. The odds of finding colonic adenoma in patients with diverticulosis is 1.3-fold higher than those without diverticulosis (95% Confidence Interval: 0.82-2.08). Adjusting for Age and sex of patients, the adjusted OR is 0.98 (95% CI: 0.60-1.58, p value=0.92) which indicates that frequency of adenoma was not higher in patient with colonic diverticulosis compared to those without diverticulosis.
Conclusion: No statistical significant association was observed between diverticulosis and adenoma/advanced adenoma. However, there is insufficient evidence to conclude absence of association due to limited power of the study. We therefore recommend to increase the sample size in future research.
Keywords: colonic adenoma, colonic diverticulosis, colonic neoplasm, colonic neoplasia
Important Dates to Remember
| JRRE Activities 2023-2024 |
Proposed Dates |
|---|---|
| Resumption of face-to-face Evidence-Based Medicine Workshop Venue to be announced once finalized. |
July 21, 2023 (Friday), 1-5pm |
| Monthly Critical Appraisal of Topics Conferences to be gaciliated by Research Coordinators per Institution | Monthly Critical Appraisal of Topics Conferences per Institution |
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2 Clinical scenarios and articles are to be sent to institutions each on August 2023, November 2023, and February 2024; |
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| Research Manuscript Workshop for level II GI Fellows-In-Training | January 6, 2024 |