Abstract
A RARE CASE OF EXTRA-GASTROINTESTINAL STROMAL TUMOR WITH LIVER METASTASIS
KP Fidel, JC Bocobo
Institute of Digestive and Liver Diseases, St. Luke’s Medical Center Quezon City
Significance: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, occurring most frequently in the stomach, jejunum and ileum. A small number may originate from outside the gastrointestinal tract such as the mesentery, omentum and peritoneum and are designated as Extra-Gastrointestinal Stromal Tumors (E-GIST). Clinicopathological features and prognosis of E-GISTs are limited due to the extremely rare incidence, much more when it presents as a metastatic disease. Hence, reporting a case of metastatic E-GIST would be valuable in extending our knowledge on this kind of rare entity.
Clinical Presentation: A 56 year-old male with a history omental mass eight years prior now presents with intermittent abdominal pain, diagnosed to have multiple hepatic lesions. Underwent liver biopsy which revealed spindle cell neoplasm, with positive immunostaining: (+) CK 117, (+) CD 34, (-) DOG-1. However, mutational analysis was not done. Patient was then started on Imatinib therapy.
Recommendation: Our existing data on metastatic E-GIST is not sufficient to conclude as to the proper management of these cases. But Imatinib therapy following complete resection of the tumor may prolong overall survival.
Keywords: case report, extra-gastrointestinal stromal tumor, liver metastasis, imatinib therapy
Important Dates to Remember
| JRRE Activities 2023-2024 |
Proposed Dates |
|---|---|
| Resumption of face-to-face Evidence-Based Medicine Workshop Venue to be announced once finalized. |
July 21, 2023 (Friday), 1-5pm |
| Monthly Critical Appraisal of Topics Conferences to be gaciliated by Research Coordinators per Institution | Monthly Critical Appraisal of Topics Conferences per Institution |
| CAT Plenary/Liver Con Dates: September 23, 2023 December 16, 2023 March 2024 (During the JAC) Resumption of face-to-face Quarterly Critical Appraisal of Topics facilitated by the JRRE |
2 Clinical scenarios and articles are to be sent to institutions each on August 2023, November 2023, and February 2024; |
| Hybrid Research Workshop 4 week asynchronous via Moodle, followed by a 1 day on-site Onsite Workshop Research Protocol Presentation for Level I GI Fellows-In-Training - Research Protocol Presentation: August 12, 2023 - Research Forums of the Tripartite Societies |
Week 1: July 15-21, 2023 Week 2: July 22-28, 2023 Week 3: July 29-August 4, 2023 Week 4: August 5-11, 2023 |
| Research Manuscript Workshop for level II GI Fellows-In-Training | January 6, 2024 |