Abstract
RADIOFREQUENCY VERSUS MICROWAVE ABLATION OF HEPATOCELLULAR CARCINOMA IN HIGH-RISK LOCATIONS
Akemi A. Kimura, MD, Stephen N. Wong, MD, FPCP, FPSG, FPSDE
University of Santo Tomas Hospital
Objectives: Locoregional interventional therapies play a leading part in the management of hepatocellular carcinoma (HCC). This study aims to compare treatment outcomes of radiofrequency ablation (RFA) versus microwave ablation (MWA) in patients with HCC in high-risk locations.
Methodology: This is a retrospective study which included HCC patients who underwent RFA or MWA. We compared the outcomes of high-risk tumors with non high-risk tumors in terms of complete ablation and recurrence rates. We also identified the predictors of survival and recurrence between RFA and MWA groups.
Results: The study included 192 HCC patients with 622 tumors in total, in which 367 were considered as high-risk. Despite differences in tumor characteristics (size p=0.002 and number p=0.001), there was no significant difference in the complete ablation rates for RFA vs MWA in high-risk tumors (92.1% and 91.7%) versus non high-risk tumors (92.5% vs 97.4%). Predictors of survival include presence of solitary tumor (p=0.008), Child Pugh score of A (p=0.025), and absence of recurrence (p=0.44). Whereas predictor of recurrence include multiple tumors (p= 0.01).
Conclusion: Radiofrequency and microwave ablation have similar efficacy profiles for the treatment of hepatocellular carcinoma in both high-risk and non-high-risk locations
Keywords: Hepatocellular Carcinoma. Radiofrequency Ablation. Microwave Ablation. High-risk Tumors.
Important Dates to Remember
| JRRE Activities 2023-2024 |
Proposed Dates |
|---|---|
| Resumption of face-to-face Evidence-Based Medicine Workshop Venue to be announced once finalized. |
July 21, 2023 (Friday), 1-5pm |
| Monthly Critical Appraisal of Topics Conferences to be gaciliated by Research Coordinators per Institution | Monthly Critical Appraisal of Topics Conferences per Institution |
| CAT Plenary/Liver Con Dates: September 23, 2023 December 16, 2023 March 2024 (During the JAC) Resumption of face-to-face Quarterly Critical Appraisal of Topics facilitated by the JRRE |
2 Clinical scenarios and articles are to be sent to institutions each on August 2023, November 2023, and February 2024; |
| Hybrid Research Workshop 4 week asynchronous via Moodle, followed by a 1 day on-site Onsite Workshop Research Protocol Presentation for Level I GI Fellows-In-Training - Research Protocol Presentation: August 12, 2023 - Research Forums of the Tripartite Societies |
Week 1: July 15-21, 2023 Week 2: July 22-28, 2023 Week 3: July 29-August 4, 2023 Week 4: August 5-11, 2023 |
| Research Manuscript Workshop for level II GI Fellows-In-Training | January 6, 2024 |