Abstract
PREDICTIVE FACTORS OF BACTERIAL INFECTIONS IN PATIENTS WITH LIVER CIRRHOSIS
Jan Catherine G. Carrera MD, Jenny Limquiaco MD, Lou Angelique Dy-Limquiaco MD, Derek Leand Tan MD
Chong Hua Hospital Fuente Osmeña , Cebu City
Background: Bacterial infection is common and accounts for major morbidity and mortality in cirrhosis. Patients with cirrhosis are in a state of immune dysfunction making them at risk to develop serious bacterial infections. This study aimed to describe the potential use of biochemical profile and inflammatory markers in identifying predictive factors of bacterial infections present in the cirrhotic population.
Methodology: This cohort study evaluated biochemical profile and inflammatory markers of cirrhotic patients. Baseline characteristics of these patients were classified based on their presence and absence of infection. Routine laboratory parameters and inflammatory based markers were analyzed.
Results: Of the 272 patients with liver cirrhosis, 172 (63.2%) patients had infection and 100 (36.7%) patients had no infection. The mean age of the studied population were 62. 67 and 60.46 in patients with and without infection respectively. The most common infections identified were pneumonia (40.12%) followed by urinary tract infection (24.42 %) and SBP (13.95 %). The most common bacteria isolated from patients were Klebsiella pneumonia, Escherichia coli, and Methicillin resistant staphylococcus aureus. Significant differences were found between CTP classification, MELD score and WBC. Furthermore, among the different inflammatory based markers, Neutrophil Lymphocyte Ratio (NLR) and Lymphocyte Monocyte Ration (LMR) were significant predictors of bacterial infection in cirrhotic patients with NLR cut off ? 4.7 and LMR ?2.26.
Conclusion: Bacterial infection prevalence is relatively high in patients with liver cirrhosis. Our study demonstrated that baseline NLR, LMR and WBC are predictors of bacterial infection in patients with cirrhosis
Important Dates to Remember
| JRRE Activities 2023-2024 |
Proposed Dates |
|---|---|
| Resumption of face-to-face Evidence-Based Medicine Workshop Venue to be announced once finalized. |
July 21, 2023 (Friday), 1-5pm |
| Monthly Critical Appraisal of Topics Conferences to be gaciliated by Research Coordinators per Institution | Monthly Critical Appraisal of Topics Conferences per Institution |
| CAT Plenary/Liver Con Dates: September 23, 2023 December 16, 2023 March 2024 (During the JAC) Resumption of face-to-face Quarterly Critical Appraisal of Topics facilitated by the JRRE |
2 Clinical scenarios and articles are to be sent to institutions each on August 2023, November 2023, and February 2024; |
| Hybrid Research Workshop 4 week asynchronous via Moodle, followed by a 1 day on-site Onsite Workshop Research Protocol Presentation for Level I GI Fellows-In-Training - Research Protocol Presentation: August 12, 2023 - Research Forums of the Tripartite Societies |
Week 1: July 15-21, 2023 Week 2: July 22-28, 2023 Week 3: July 29-August 4, 2023 Week 4: August 5-11, 2023 |
| Research Manuscript Workshop for level II GI Fellows-In-Training | January 6, 2024 |