Abstract
OCTREOTIDE FOR THE PREVENTION OF POST-ERCP PANCREATITIS – A RETROSPECTIVE STUDY
De Chavez BJT, Lapus IA.
Cardinal Santos Medical Center, Department of Internal Medicine, Section of Gastroenterology; December 2017
Background: Post ERCP pancreatitis (PEP) remains to be the most common serious adverse event of the procedure. Prophylactic octreotide administration has been demonstrated to prevent PEP but several studies have yielded different results. The study investigated whether giving octreotide on average-risk and high-risk patients decreased the occurrence of PEP.
Methodology: A retrospective cohort was used, utilizing data from Cardinal Santos Medical Center. A total of 99 subjects who underwent ERCP with at least 1 risk factor were included. The following data were obtained: age, sex, previous PEP, normal bilirubin levels, difficult cannulation (>10mins), pancreatic duct cannulation, pancreatic duct contrast injection, and pancreatic duct sphincterotomy. Average risk (<3 risk factors) and high risk (?3 risk factors) patients, octreotide administration and PEP occurrence were identified. Statistical analysis was performed using SPSS v 20.0.
Results: Study population consisted of 99 post ERCP patients with risk. PEP occurred in 23.33% of patients given octreotide and 24.64% of patients without premedication but was not statistically significant (p value=1.000). Average risk patients in the octreotide group had higher PEP than the no premedication group (25% vs. 20.51%) but was not statistically significant (p value=0.7295). High risk patients in the octreotide group had lower PEP than the no premedication group (50% vs 66.67%) but was not statistically significant (p value=1.000)
Conclusion: Our data did not show any significant difference in giving octreotide and not giving premedications in preventing PEP occurrence.
Keywords: Retrospective Cohort; Octreotide; Post-ERCP pancreatitis
Important Dates to Remember
| JRRE Activities 2023-2024 |
Proposed Dates |
|---|---|
| Resumption of face-to-face Evidence-Based Medicine Workshop Venue to be announced once finalized. |
July 21, 2023 (Friday), 1-5pm |
| Monthly Critical Appraisal of Topics Conferences to be gaciliated by Research Coordinators per Institution | Monthly Critical Appraisal of Topics Conferences per Institution |
| CAT Plenary/Liver Con Dates: September 23, 2023 December 16, 2023 March 2024 (During the JAC) Resumption of face-to-face Quarterly Critical Appraisal of Topics facilitated by the JRRE |
2 Clinical scenarios and articles are to be sent to institutions each on August 2023, November 2023, and February 2024; |
| Hybrid Research Workshop 4 week asynchronous via Moodle, followed by a 1 day on-site Onsite Workshop Research Protocol Presentation for Level I GI Fellows-In-Training - Research Protocol Presentation: August 12, 2023 - Research Forums of the Tripartite Societies |
Week 1: July 15-21, 2023 Week 2: July 22-28, 2023 Week 3: July 29-August 4, 2023 Week 4: August 5-11, 2023 |
| Research Manuscript Workshop for level II GI Fellows-In-Training | January 6, 2024 |